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Patients Not Presently Receiving Levodopa: When it is evident that more levodopa is needed, Syndopa 275, at a dosage of 1 tablet 3-4 times a day, should be substituted.
If further titration is still necessary, dosage with Syndopa 275 may be increased by ½ or 1 tablet every 1-2 days to a maximum of 8 tablets per day; alternatively, dosage may be titrated to 6 tablets of Syndopa 275 a day and further adjusted with increments of levodopa.
Patients Receiving Levodopa: When patients are receiving levodopa, it must be discontinued at least 8 hours before Syndopa is started. A daily dosage of Syndopa should be chosen that will provide approximately 25% of the previous levodopa daily dosage.
Levodopa Requirement >1500 mg/day: For most patients, the suggested starting dose is 1 tablet of Syndopa 275, 3-4 times a day.
Adjustment in dosage may be made as necessary by adding or omitting ½ or 1 tablet a day.
Current evidence indicates that other antiparkinsonian drugs may be continued while Syndopa is being administered but their dosage may have to be adjusted.
